RESUMO
The authors report comparative analysis of the efficacy of cytoprotectors and basal therapy used to treat widespread forms of psoriasis. Combination of both modalities including remaxol and ademetionine increases the effectiveness of the treatment by 23% as appears from the decrease of PASI of 89.6% patients from 23.6 +/- 2.2 to 5.7 +/- 2.2 scores.
Assuntos
Psoríase/tratamento farmacológico , S-Adenosilmetionina/administração & dosagem , Succinatos/administração & dosagem , Vitaminas/administração & dosagem , Antioxidantes/administração & dosagem , Vias de Administração de Medicamentos , Monitoramento de Medicamentos , Quimioterapia Combinada , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Substâncias Protetoras/administração & dosagem , Psoríase/fisiopatologia , Índice de Gravidade de Doença , Resultado do TratamentoRESUMO
Experiments on erythrocytes of patients were used to study the influence of remaxol and ademetionin on the exchange of thiols. The values of thioldisulfide exchange indicators were determined in the beginning of the period of observation and at the end of every week within one month. Patients who received hepato-protectors in combination with higher-level thiols showed positive dynamics in disease treatment as compared to patients receiving standard therapy. The concentration of restored glutathione and proteins of hydrosulfide groups and the activity of glutathione peroxidase are informative criteria for estimating the course of disease current and the efficiency of therapy of widespread forms of psoriasis.